Monoclonal Antibodies Prevent Severe COVID-19 Disease, Hospitalization and Death

Fast take:

  • Monoclonal antibody therapy is an important but underused treatment for preventing severe disease and death from COVID-19.
  • Monoclonal antibody therapy is the best available therapy for people over 12 years of age who test positive for COVID-19 and who have risk factors for severe disease.
  • It reduces hospitalizations and death by 75% to 85%.
  • It is provided free of charge to any US resident.

Real fast take: Monoclonal antibody therapy is safe; it’s effective and it saves lives: use it!

Monoclonal Antibody Therapy:

Monoclonal antibody therapy is the most effective treatment to date to prevent patients with mild or moderate cases of COVID-19 from developing severe disease, hospitalization, ICU admission, intubation and death. Monoclonal antibody therapy reduces the number of viruses in the patient and lessens symptom severity. It has been demonstrated to reduce COVID-19 hospitalizations and death by 75% to 85%.

When administered within 10 days of onset of COVID-19 symptoms, this one-time treatment is highly effective in killing the virus, preventing symptoms from worsening, and avoiding hospitalization. When administered early, many patients report a rapid and complete resolution of symptoms.

Please remember, monoclonal antibody therapy is not a substitution for vaccination. Vaccination is still the best first line of defense against COVID-19.

What is monoclonal antibody therapy?

This medication consists of antibodies to the virus, quite similar to the antibodies that your own body makes when you are vaccinated or infected with the virus. However, the therapy gives patients an immediate boost in the number of these antibodies. These antibodies are synthesized in a lab. They do not come from other patients.

The monoclonal antibodies kill the virus early before the virus can multiply and make a patient very sick. These antibodies attack the so-called spike protein on the virus, blocking the virus from attaching to a patient’s cells. This slows the growth of the virus within the patient, while the patient’s own body revs up its own natural immunity systems.

The US Food and Drug Administration (FDA) issued emergency use authorization for monoclonal treatments for COVID-19 patients or exposed people, aged 12 and older, who are at moderate or high risk for developing severe COVID-19 disease. This includes many or most adult COVID-19 patients in the US.

Monoclonal antibody therapy involves administering a small amount of medication intravenously (into your vein) over 20 to 30 minutes, or it can be administered subcutaneously (as injections under your skin). The single treatment is followed by an hour of patient monitoring.

This therapy can be administered in an outpatient medical clinic, an emergency room, a long-term care setting such as a nursing home or even in a patient’s home.

For those who would like a more in-depth discussion of the benefits of monoclonal antibody therapy, here is the link to a one hour webinar, with 5 Massachusetts experts, which I moderated for the Massachusetts Health & Hospital Association’s physician leaders on November 22, 2021.

Which patients are eligible to receive monoclonal antibody therapy?

This medication is available for use in patients who are not yet sick enough to be hospitalized and who are at an increased risk for progression to severe disease, hospitalization, and death and who are at least 12 years old.

This therapy can also be given to high-risk patients (for example, nursing home residents) who have simply been exposed to COVID-19, prior to testing positive for COVID-19. We call this prophylactic therapy.

Who is considered at increased risk for severe COVID-19 disease, and therefore an ideal candidate for early treatment with this life-saving disease as an outpatient?

  • Anyone who is
    • Overweight or Body Mass Index (BMI) of greater than 25: use this link to calculate your BMI or
    • Over 65 years old, or
    • Pregnant, or
    • Immunocompromised, or
    • Dependent on a medical technology such as a feeding tube
  • OR any patients who suffer from:
    • Chronic kidney disease, or
    • Diabetes, or
    • Heart disease, or
    • High blood pressure, or
    • Chronic lung disease including COPD, or
    • Sickle cell disease

Please see the complete, regularly updated list of criteria from the Commonwealth of Massachusetts at this link.

If you have tested positive for COVID-19 within the past 10 days, please contact your healthcare professional to discuss monoclonal antibody therapy. The sooner, the better.

Anywhere within the United States, US patients can click here to find a treatment center near you.

Are there side effects to monoclonal antibody treatment?

Allergic reactions can happen with the administration of this medication, like any medication. Patients are therefore evaluated for the development of any signs of allergic reaction for one hour after this one-time treatment.

Most experts believe that these antibodies may limit your own body’s ability to develop an immune response during a subsequent COVID-19 vaccination for a brief period of time. Hence currently, it is recommended that patients delay COVID-19 vaccination for 90 days after receiving monoclonal antibody treatment. Other rare side effects can occur. Feel free to discuss this with your healthcare provider.

Joint MMS – MA DPH announcement:

Just this week, the Commonwealth of Massachusetts’ Department of Public Health and the Massachusetts Medical Society issued this joint statement, strongly urging health care practitioners and providers to consider using monoclonal antibody therapy for their patients who are infected with COVID-19 or have been exposed to COVID-19 when clinically appropriate.

In Summary:

Do yourself a favor; do your family and friends a favor and do me a favor; if you test positive for COVID-19 and qualify for this life saving treatment, seek it out. The life you save may be your own.

Continue Reading

Most Physicians Hate Their Computer: It Needn’t be That Way

While the causes of physician burnout (and clinician burnout more generally) are multifactorial, inefficient electronic medical records (EHRs) and their associated disrupted workflows consistently top the list of the main drivers of physician burnout.  Atul Gawande wrote an eloquent piece on the subject entitled, Why doctors Hate Their Computers, in which Dr. Gawande notes “I’ve come to feel that a system that promised to increase my mastery over my work has, instead, increased my work’s mastery over me.”

There are EHR optimization pearls your organization can take.

But there are practical EHR optimization pearls any organization can take to reduce administrivia driven burnout. Last week, I co-authored a paper for the Joint Massachusetts Medical Society (MMS) – Massachusetts Health & Hospital Association (MHA) Task Force on Physician Burnout in partnership with the Reliant Medical Group: Changing the EHR from a Liability to an Asset to Reduce Physician Burnout. 

This paper includes more than a dozen electronic health record (EHR) optimization techniques organizations can take today to improve the usability of the EHR as well as its associated workflows, in order to reduce unnecessary administrative burden for physicians and other clinicians.

Our message is that there are many interventions compassionate leaders can take today to help mitigate the drivers of clinician burnout.  We would be happy to hear what has worked for you.

Continue Reading

Medicine is the Deadliest Profession: It Needn’t Be

10 Steps to Prevent Physician Suicide for 2019

Each year, the graduating classes of three average size medical schools don’t add a single physician to the US workforce; they simply replace the 300 to 400 physicians the American Foundation for Suicide Prevention estimates kill themselves each year. We lose a doctor a day to suicide.

In a recent blog post a healthcare CEO asked, “Is the rate of physician suicide statistically different from that of other highly paid professionals?” Yes.

The American Psychiatric Association reported that physicians have the highest suicide rate of any profession at their annual meeting in 2018, higher in fact than active duty military personnel.

The same is true for Finland, Norway, Australia, Singapore and China.

The time to prevent physician suicide, rigorously document its occurrence, remove the stigma of seeking mental health care and to care for suicide victims’ workplace survivors is long overdue.

Physicians know how to stay healthy. This is why it is especially tragic that the only cause of death where the risk to physicians is higher than the general public is suicide.

Worse, we’ve been aware of this slow motion tragedy for generations and it is largely preventable. S. Dana Hubbard, M. D., Director, Bureau of Public Health Education, New York City Department of Health published the fact that physicians lead the list of suicides by professions in the American Journal of Public Health, in 1922.

Almost a century later mystery still shrouds the exact number of physician suicides each year as families and employers alike are reluctant to tell the truth in public, due to the fear of stigma. Medical examiners may have difficulty distinguishing intentional from unintentional traumatic deaths. Even when a suicide is accurately determined, there is no consistent reporting of the victim’s occupation.

Most experts agree the physician suicide rate is roughly twice that of the US population in general, and it is even worse for female physicians. A meta-analysis of physician suicide published in the American Journal of psychiatry demonstrated that both male and females physicians are more likely to die by suicide compared to the general population (1.41 times more likely for male physicians and 2.27 times more likely for female physicians).

The US healthcare system is killing physicians.

Students and young Physicians have been documented to be actually more resilient and less depressed than the US average. Then we are subjected to stress, moral distress and trained to ignore the symptoms of depression until it is too late. A study published in the Archives of General Psychiatry demonstrated that the rate of depression among physicians immediately prior to entering internship was 3.9%. During internship, this rate skyrocketed to 25.7%.

Factors contributing to the epidemic of physician suicide include:

  1. Repetitive exposure to death and dying
  2. Exact knowledge of (and ready access to) lethal means
  3. Stigma associated with asking for mental healthcare and
  4. Our profession’s excessive dependence on self-reliance.

While the first two factors above are likely inherent to the profession, the latter two factors driving suicide are amenable to mitigation.

Here are Ten Suggestions for 2019:

  1. Put an end to the silent curriculum (Don’t ask for help. Never show weakness.”) in physician training programs.

Part of the reason physicians don’t ask for help is that in training we were taught the unwritten rule: “Don’t ask for help and never show weakness.”

On my first day of surgical internship, I was naturally a bit apprehensive, given the enormous privilege and responsibility I was about to be given, caring for, and operating on some of the most ill patients in one of the finest academic medical centers in the US. I was shocked and taken aback by the advice the entire group of us surgical interns were given by the senior attending surgeon, tasked with orienting us. He said, “Always remember that while you are here… you are swimming with sharks. So don’t make waves, and if you are bit, don’t bleed.” It is this kind of abusive attitude which I am confident cost one of my female classmates her life, during her surgical residency when she killed herself halfway across the country in another surgical training program.

We must incorporate wellness into both the written (and silent) curriculum.

2. The Physicians need better access to mental health care without fear of punishment for admitting they need help.

Dr. Michell Hardison, a well-respected family doctor in Raleigh NC chose suicide over psychiatric care for his depression. His daughter Anna Hardison Severn revealed, “He was 100% positive that if he came forward and said he needed help that there would be a reprisal of some kind.”

State medical boards are responsible for licensing physicians and protecting the public by ensuring physicians meet high standards. There is nothing wrong with medical boards asking physicians if they have a medical or psychiatric condition which might lower the quality of the care they deliver. They should not however ask if a physician has ever been under the care of a mental health professional. For if they do this, physicians will forgo needed care which could harm the doctor and jeopardize the quality of the care for their patients.

The Federation of State Medical Boards (FSMB) Workgroup on Physician Wellness and Burnout made 35 recommendations to better address physician burnout. These recommendations should be adopted by all states. They advise against asking probing personal questions regarding a physician’s mental health. The FSMB specifically recommended that state medical boards indicate“it is not only normal but anticipated and acceptable for a physician to feel overwhelmed from time to time and to seek help when appropriate.”

3. Not only should the electronic medical record must be optimized, but processes and systems must be optimized in order to get the most out of this technology and improve user satisfaction.

How it is that healthcare is the only industry where digitization/computerization has decreased worker productivity? The epidemic of physician burnout, driven by administrative hassles, loss of professional autonomy and increasing workloads is contributing to physician burnout, depression and suicide.

It is inexcusable that for every hour physicians spend facing a patient in their office, they are forced to spend two hours tending to desk work and documentation in the electronic medical record.

At UC Davis Medical Health, Scott MacDonald, MD, FACEP demonstrated that by optimizing their electronic medical record’s use, the health system could both dramatically increase physician satisfaction with their EHR and improve their quality of life. They were able to eliminate over 25 hours of unproductive, unnecessary busy work from their physicians’ schedule each month! Imagine how much more time physicians could spend meaningfully caring for their patients and achieving work life balance if this innovation were to be adopted nationwide.

4. Stop the stigma. Employers of physicians, including hospitals, physician groups and residencies must encourage and normalize accessing mental health care.

We must destigmatize and treat physician depression in order to prevent suicide. One study found that access to residency positions was limited for fully qualified students who had requested psychiatric counseling! Only when seeking out a councilor is considered “normal” will physicians ask for help when they need it. All too often, physicians are encouraged to keep vulnerabilities hidden and not ask for help.

5. The practice of requiring medical students and residents to obtain mental health care at their own institution limits confidentiality and should be eliminated.

Until the stigma of obtaining mental health is completely relegated to the ash-bin of history, the confidentiality of accessing such services is critical, particularly for physicians in training. Some student and resident health plans require trainees to obtain healthcare at their own institution, limiting confidentiality for both physical and psychiatric conditions. This paternalistic and antiquated requirement should be eliminated.

6. Peer support should be available at times of great vulnerability:

Medical errors, patient injuries and patient deaths are obviously painful for the patient’s families. Less well understood is the fact that physicians also suffer emotionally in such circumstances, particularly if they believe they have somehow failed their patient and begin to second-guess their own competence.

In times of great stress, such as these or when facing a medical malpractice lawsuit, physicians are extra vulnerable to depression and suicide. It is at these times that confidential peer support, advice from a colleague who has endured the same stressor is most helpful. Employers should plan ahead for such events and offer well-structured and readily available confidential peer to peer support programs to their employed and affiliated physicians.

7. We must accurately keep track of suicide rates by profession. State medical examiners should record the occupation of all suicide victims, including what school they are attending if they are in college or graduate school.

Only then can we identify opportunities for improvement and evaluate whether our interventions are effective in stemming the tide of this horrific slow motion tragedy.

This would capture both the number of physicians / medical students who are committing suicide, and also spotlight any outlier institutions.

8. Postvention: Care for the bystanders after a physician suicide is essential.

Post-suicide counseling and peer support is especially important after a colleague has committed suicide. Toolkits such as the American Foundation for Suicide Prevention’s toolkits are available on line. There is even a toolkit specifically designed for medical schools to utilize after a medical student suicide.

9. Encourage all physicians to select their own trusted primary care physician (and regularly check in with that physician).

All too often physicians follow the dictum, “physician heal thyself.” Employers and affiliated institutions should encourage all medical students, residents and practicing physicians to choose their own trusted primary care physician. In addition to obtaining objective evidence based care from a personal physician, these trusted doctors represent another touch point from which distressed physicians can obtain emotional support.

10. Accessing medical care, whether physical or psychiatric, should be modeled by mentor physicians.

Organizational leaders should model self-care, access mental health care publicly and publicly reinforce the necessity of a healthy work-life balance.

Together we can end the epidemic of physician suicide. Let’s make it happen in 2019.

Continue Reading