Monoclonal Antibodies Prevent Severe COVID-19 Disease, Hospitalization and Death

Fast take:

  • Monoclonal antibody therapy is an important but underused treatment for preventing severe disease and death from COVID-19.
  • Monoclonal antibody therapy is the best available therapy for people over 12 years of age who test positive for COVID-19 and who have risk factors for severe disease.
  • It reduces hospitalizations and death by 75% to 85%.
  • It is provided free of charge to any US resident.

Real fast take: Monoclonal antibody therapy is safe; it’s effective and it saves lives: use it!

Monoclonal Antibody Therapy:

Monoclonal antibody therapy is the most effective treatment to date to prevent patients with mild or moderate cases of COVID-19 from developing severe disease, hospitalization, ICU admission, intubation and death. Monoclonal antibody therapy reduces the number of viruses in the patient and lessens symptom severity. It has been demonstrated to reduce COVID-19 hospitalizations and death by 75% to 85%.

When administered within 10 days of onset of COVID-19 symptoms, this one-time treatment is highly effective in killing the virus, preventing symptoms from worsening, and avoiding hospitalization. When administered early, many patients report a rapid and complete resolution of symptoms.

Please remember, monoclonal antibody therapy is not a substitution for vaccination. Vaccination is still the best first line of defense against COVID-19.

What is monoclonal antibody therapy?

This medication consists of antibodies to the virus, quite similar to the antibodies that your own body makes when you are vaccinated or infected with the virus. However, the therapy gives patients an immediate boost in the number of these antibodies. These antibodies are synthesized in a lab. They do not come from other patients.

The monoclonal antibodies kill the virus early before the virus can multiply and make a patient very sick. These antibodies attack the so-called spike protein on the virus, blocking the virus from attaching to a patient’s cells. This slows the growth of the virus within the patient, while the patient’s own body revs up its own natural immunity systems.

The US Food and Drug Administration (FDA) issued emergency use authorization for monoclonal treatments for COVID-19 patients or exposed people, aged 12 and older, who are at moderate or high risk for developing severe COVID-19 disease. This includes many or most adult COVID-19 patients in the US.

Monoclonal antibody therapy involves administering a small amount of medication intravenously (into your vein) over 20 to 30 minutes, or it can be administered subcutaneously (as injections under your skin). The single treatment is followed by an hour of patient monitoring.

This therapy can be administered in an outpatient medical clinic, an emergency room, a long-term care setting such as a nursing home or even in a patient’s home.

For those who would like a more in-depth discussion of the benefits of monoclonal antibody therapy, here is the link to a one hour webinar, with 5 Massachusetts experts, which I moderated for the Massachusetts Health & Hospital Association’s physician leaders on November 22, 2021.

Which patients are eligible to receive monoclonal antibody therapy?

This medication is available for use in patients who are not yet sick enough to be hospitalized and who are at an increased risk for progression to severe disease, hospitalization, and death and who are at least 12 years old.

This therapy can also be given to high-risk patients (for example, nursing home residents) who have simply been exposed to COVID-19, prior to testing positive for COVID-19. We call this prophylactic therapy.

Who is considered at increased risk for severe COVID-19 disease, and therefore an ideal candidate for early treatment with this life-saving disease as an outpatient?

  • Anyone who is
    • Overweight or Body Mass Index (BMI) of greater than 25: use this link to calculate your BMI or
    • Over 65 years old, or
    • Pregnant, or
    • Immunocompromised, or
    • Dependent on a medical technology such as a feeding tube
  • OR any patients who suffer from:
    • Chronic kidney disease, or
    • Diabetes, or
    • Heart disease, or
    • High blood pressure, or
    • Chronic lung disease including COPD, or
    • Sickle cell disease

Please see the complete, regularly updated list of criteria from the Commonwealth of Massachusetts at this link.

If you have tested positive for COVID-19 within the past 10 days, please contact your healthcare professional to discuss monoclonal antibody therapy. The sooner, the better.

Anywhere within the United States, US patients can click here to find a treatment center near you.

Are there side effects to monoclonal antibody treatment?

Allergic reactions can happen with the administration of this medication, like any medication. Patients are therefore evaluated for the development of any signs of allergic reaction for one hour after this one-time treatment.

Most experts believe that these antibodies may limit your own body’s ability to develop an immune response during a subsequent COVID-19 vaccination for a brief period of time. Hence currently, it is recommended that patients delay COVID-19 vaccination for 90 days after receiving monoclonal antibody treatment. Other rare side effects can occur. Feel free to discuss this with your healthcare provider.

Joint MMS – MA DPH announcement:

Just this week, the Commonwealth of Massachusetts’ Department of Public Health and the Massachusetts Medical Society issued this joint statement, strongly urging health care practitioners and providers to consider using monoclonal antibody therapy for their patients who are infected with COVID-19 or have been exposed to COVID-19 when clinically appropriate.

In Summary:

Do yourself a favor; do your family and friends a favor and do me a favor; if you test positive for COVID-19 and qualify for this life saving treatment, seek it out. The life you save may be your own.

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Physician Burnout is a Public Health Crisis Which Needs to be Addressed Now

Last week, the Massachusetts Medical Society – Massachusetts Health & Hospital Association Joint Task Force on Physician Burnout in association with the Harvard T.H. Chan School of Public Health, and Harvard Global Health Institute released a white paper entitled, A CRISIS IN HEALTH CARE: A CALL TO ACTION ON PHYSICIAN BURNOUT.

My friend and colleague, Dr. Alain Chaoui, President of MMS, Michelle Williams, Professor and Dean of the Faculty, Harvard T.H. Chan School of Public Health and I wrote an Op-Ed which appeared in The Boston Globe last week: Doctor burnout is real. And it’s dangerous. In both publications we advocate for for removal of barriers to mental healthcare for clinicians, the employment of Chief Wellness Officers at healthcare institutions and optimization of the current generation of electronic medical records (EMRs).

These recommendations received widespread attention, as they were simultaneously covered by Priyanka Dayal McCluskey in her front page Boston Globe story: Physician burnout now essentially a public health crisis and by Heather Landi in Healthcare Infomatics: Research: Physician Burnout is a Public Health Crisis; Improving EHR Usability is Critical.

The most valuable asset of any organization is the worker on the front-lines. Today, too many of these clinicians are bleeding.

Let’s work together to bring these three recommendations to fruition while helping bring joy back to caring in 2019.

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The Columbia Gas explosions and Lawrence General Hospital: What they can Teach Us About the Misguided Massachusetts Question 1 Ballot Initiative:

At 4:30 PM, September 13, leaders at Lawrence General Hospital were alerted to multiple natural gas explosions in Lawrence and adjacent Andover and North Andover. That day, gas explosions would simultaneously burn up to 80 houses, injure dozens of people and kill one teenager. Thousands were evacuated from their homes. Many of those residents remain unable to return home. One of the witnesses on the scene of the explosions noted “It looked like Armageddon.” The smoke in the air was reminiscent of lower Manhattan on 9/11. At Ground Zero was Lawrence General Hospital. Upon learning of the incident, Lawrence General Hospital leaders immediately shut down the hospital’s own natural gas supply out of an abundance of caution. Raging fires could be seen burning across the river from the hospital. Smoke drifted onto their hospital campus.

“At the time, I had the horrible thought; what if the nurse staffing ratio law had actually been implemented?”

Leaders at Lawrence General Hospital activated their emergency management plan before the first patient arrived at their doors. This emergency plan included notifying their staff, both within the hospital and those who had the day off.

Everybody did what they could. For example, the Chief Financial Officer, Felix Mercado, (who is an accountant by training, not a clinician) left his office to see how he could best serve the patients and their families in the emergency room. He actually served as a translator that day. Other administrators put on rubber gloves and made sandwiches for the families. The staff at Lawrence General Hospital are proud of the way their community pulled together, as they knew it would in times such as these.

Of the thirteen injured people who were rushed to their emergency room that day, only one person had to be airlifted out, to Massachusetts General Hospital. The rest of the patients were cared for locally at Lawrence General Hospital, a well-known resource for their community.

What if the misguided Question 1 ballot initiative were law that day? Robin Hynds, MSN, RN, CPHM, Executive Director Merrimack Health Network responded that they probably would have been forced to break the law and suffer heavy fines for doing the right thing. She said, “What can we do? Of course we will always take care of the patients. We are the closest hospital to the incident and the best able to provide care locally.” “We support the community. It’s the right thing to do.”

Robin also noted, “At the time, I had the horrible thought; what if the nurse staffing ratio law had actually been implemented? We would have had some hard choices to make, and certainly waits for less urgent care would have been much longer.”

The Boston Globe urges us, “Vote ‘no’ on Question 1. The Nurse staffing ratio is wrong for Mass.

The Lawrence General Hospital leaders I spoke to were proud of the way their on-call and off-duty staff responded. Robin shared, “Many of our nurses came in, on their time off, out of the goodness of their hearts. They were literally running in through the front doors. Physicians too, including trauma surgeons.”

If Question 1 passes this November 6, it would be illegal for hospitals to admit both their routine patients and an unexpected rush of patients from a tragic accident such as the Columbia Gas explosions. This is because the ballot initiative requires a fixed at-all-times rigid number of patients to be assigned to each nurse.

Question 1 is a disaster waiting to happen. The proposed law would require all hospitals to adopt the same rigid, scientifically unproven, one-size-fits-all ratios of nurses-to-patients, at all times – regardless of a hospital’s size, location, or needs of those receiving care.

Question 1 would override the professional judgement and experience of nurses in favor of a rigid government mandate (based on numbers that have no scientific validity). At the bedside, such a law would take real time decision-making power away from professional nurses. In the current system, care team assignments are made based on the ever changing needs of the patients and skill set of nurses.

Question 1 would limit the services hospitals can provide at any given time if they cannot provide enough nurses to fulfill the ratios. Emergency room wait times would dramatically increase, other services will be delayed, and patients would be forced to travel extended distances for care as hospitals scramble to assign and re-assign nurses to fulfill each ratio as the number of patients fluctuates.

Question 1 would be ridiculously complex to implement: I urge you to read the ballot initiative and see for yourself: For example, it specifies 4 different nurse to patient ratios in the Emergency Department (from 1:1 for “critical patients,” 1:2 for “critical stable patients;” 1:3 for “urgent stable patients,” and 1:5 for “non-urgent stable patients.”) How could this even be implemented in the ED, where patients’ conditions change minute by minute?

Isn’t healthcare already expensive enough in Massachusetts? The Massachusetts Health Policy Commission, an independent state agency, recently issued a report that the ballot question would cost upwards of $900 million annually.

Question 1 would cripple community hospitals. Some community hospitals, perhaps yours, would be forced to close if Question 1 passes. This is particularly true for hospitals outside of Boston. Other hospitals will be forced to make painful, significant service reductions in order to keep their doors open.

The Boston Globe states, “Vote ‘no’ on Question 1. The Nurse staffing ratio is wrong for Mass.”

I am a physician and I am voting No on 1. I urge you to vote no on Question 1 too.

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